International Journal of Pediatric Otorhinolaryngology
Volume 74, Issue 8 , Pages 864-868 , August 2010

Mucin gene expression and mouse middle ear epithelium

  • Joseph E. Kerschner

      Affiliations

    • Division of Pediatric Otolaryngology, Medical College of Wisconsin, Children's Hospital of Wisconsin, 9000 W. Wisconsin Avenue, Milwaukee, WI 53226, United States
    • Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Children's Hospital of Wisconsin, 9000 W. Wisconsin Avenue, Milwaukee, WI 53226, United States
    • Corresponding Author InformationCorresponding author at: Division of Pediatric Otolaryngology, Medical College of Wisconsin, Children's Hospital of Wisconsin, 9000 W. Wisconsin Avenue, Milwaukee, WI 53226, United States. Tel.: +1 414 266 6476; fax: +1 414 266 2693.
    • ,
  • Jizhen Li

      Affiliations

    • Otitis Media Research Center, University of Minnesota, Minneapolis, MN, United States
    • ,
  • Katsuyuki Tsushiya

      Affiliations

    • Otitis Media Research Center, University of Minnesota, Minneapolis, MN, United States
    • ,
  • P. Khampang

      Affiliations

    • Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Children's Hospital of Wisconsin, 9000 W. Wisconsin Avenue, Milwaukee, WI 53226, United States

Received 5 April 2010 ,Revised 21 April 2010 ,Accepted 27 April 2010.

References 

  1. Kerschner JE, Meyer TK, Burrows A. Chinchilla middle ear epithelial mucin gene expression in response to inflammatory cytokines. Arch. Otolaryngol. Head Neck Surg. 2004;130(October (10)):1163–1167
  2. Samuel EA, Burrows A, Kerschner JE. Cytokine regulation of mucin secretion in a human middle ear epithelial model. Cytokine. 2008;41(January (1)):38–43
  3. Ubell ML, Kerschner JE, Wackym PA, Burrows A. MUC2 expression in human middle ear epithelium of patients with otitis media. Arch. Otolaryngol. Head Neck Surg. 2008;134(January (1)):39–44
  4. Kerschner JE. Mucin gene expression in human middle ear epithelium. American Laryngological, Rhinological and Otological Society Thesis. Laryngoscope. 2007;117(September (9)):1666–1676
  5. Diamond G, Legarda D, Ryan LK. The innate immune response of the respiratory epithelium. Immunol. Rev. 2000;173(February):27–38
  6. Tsuchiya K, Kim Y, Ondrey FG, Lin J. Characterization of a temperature-sensitive mouse middle ear epithelial cell line. Acta Otolaryngol. 2005;125(August (8)):823–829
  7. Escande F, Porchet N, Bernigaud A, Petitprez D, Aubert JP, Buisine MP. The mouse secreted gel forming micin gene cluster. Biochem. Biophys. Acta. 2004;1676(February (3)):240–250
  8. Trune DR, Zheng QY. Mouse models for human otitis media. Brain Res. 2009;1277(June):90–103
  9. Chun YM, Moon SK, Lee HY, Webster P, Brackmann DE, Rhim JS, et al. Immortalization of normal adult human middle ear epithelial cells using a retrovirus containing the E6/E7 genes of human papillomavirus type 16. Ann. Otol. Rhinol. Laryngol. 2002;111(June (6)):507–517
  10. Shuto T, Imasato A, Jono H, Sakai A, Xu H, Watanabe T, et al. Glucocorticoids synergistically enhance nontypeable Haemophilus influenzae-induced Toll-like receptor 2 expression via a negative cross-talk with p38 MAP kinase. J. Biol. Chem. 2002;277(May (19)):17263–17270
  11. Kubba H, Pearson JP, Birchall JP. The aetiology of otitis media with effusion: a review. Clin. Otolaryngol. Allied Sci. 2000;25(June (3)):181–194
  12. Lang T, Hansson GC, Samuelsson T. Gel-forming mucins appeared early in metazoan evolution. Proc. Natl. Acad. Sci. U.S.A. 2007;104(October (41)):16209–16214
  13. Malmberg EK, Noaksson KA, Phillipson M, Johansson ME, Hinojosa-Kurtzberg M, Holm L, et al. Increased levels of mucins in the cystic fibrosis mouse small intestine, and modulator effects of the MUC1 mucin expression. Am. J. Physiol. Gastrointest. Liver Physiol. 2006;291(August (2)):G203–G210
  14. Caramori G, Casolari P, Di Gregorio C, Saetta M, Baraldo S, Boschetto P, et al. MUC5AC expression is increased in bronchial submucosal glands of stable COPD patients. Histopathology. 2009;55(September (3)):321–331
  15. Dogru M, Matsumoto Y, Okada N, Igarashi A, Fukagawa K, Shimazaki J, et al. Alterations of the ocular surface epithelial MUC16 and globlet cell MUC5AC in patients with atopic keratoconjunctivitis. Allergy. 2008;63(October (10)):1324–1334
  16. Kirkham S, Kolsum U, Rousseau K, Singh D, Vestbo J, Thornton DJ. MUC5B is the major mucin in the gel phase of sputum in chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 2008;178(November (10)):1033–1039
  17. Elsheikh MN, Mahfouz ME. Up-regulation of MUC5AC and MUC5B mucin genes in nasopharyngeal respiratory mucosa and selective up-regulation of MUC5B in middle ear in padiatric otitis media with effusion. Laryngoscope. 2006;116(March (3)):365–369
  18. Lin J, Tsuboi Y, Rimell F, Liu G, Toyama K, Kawano H, et al. Expression of mucins in mucoid otitis media. J. Assoc. Res. Otolaryngol. 2003;4(September (3)):384–393
  19. Kerschner JE, Khampang P, Erbe CB, Kolker A, Cioffi JA. Mucin gene 19 (MUC19) expression and response to inflammatory cytokines in middle ear epithelium. Glycoconj. J. 2009;26(December (9)):1275–1284
  20. Samuels TL, Handler E, Syring ML, Pajewski NM, Blumin JH, Kerschner JE, et al. Ann. Otol. Rhinol. Laryngol. 2008;117(September (9)):688–695
  21. Packer LM, Williams SJ, Callaghan S, Gotley DC, McGuckin MA. Expression of the cell surface mucin gene family in adenocarcinomas. Int. J. Oncol. 2004;25(October (4)):1119–1126
  22. Lee HM, Kim DH, Kim JM, Lee SH, Hwang SJ. MUC8 mucin gene up-regulation in chronic rhinosinusitis. Ann. Otol. Rhinol. Laryngol. 2004;113(August (8)):662–666
  23. Choi JY, Kim JY, Kim CW, Ho JS, Lee KD, Yoo JB, et al. IL-1beta promotes the ciliogenesis of human middle ear epithelial cells: possible linkage with the expression of mucin gene 8. Acta Otolaryngol. 2005;125(March (3)):260–265

☆ Portions of this manuscript presented at the Association for Research in Otolaryngology Annual Meeting, Baltimore, MD, February, 2009.

PII: S0165-5876(10)00205-3

doi: 10.1016/j.ijporl.2010.04.014

International Journal of Pediatric Otorhinolaryngology
Volume 74, Issue 8 , Pages 864-868 , August 2010

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