International Journal of Pediatric Otorhinolaryngology
Volume 74, Issue 7 , Pages 743-746 , July 2010

The lipid laden macrophage index as a marker of aspiration in patients with type I and II laryngeal clefts

Received 7 January 2010 ,Revised 15 March 2010 ,Accepted 16 March 2010.

References 

  1. Cohen SR. Cleft larynx: a report of seven cases. Ann. Otol. Rhinol. Laryngol. 1975;84:747–756
  2. Armitage EN. Larygnotracheo-esophageal cleft. Anaesthesia. 1984;39:706–713
  3. Evans JG. Management of the cleft larynx and tracheosophageal clefts. Ann. Otol. Rhinol. Laryngol. 1985;94:627–630
  4. Benjamin B, Inglis A. Minor congenital laryngeal clefts: diagnosis and classification. Ann. Otol. Rhinol. Laryngol. 1989;98:417–420
  5. Corwin RW, Irwin RS. The lipid-laden alveolar macrophage as a marker of aspiration in parenchumal lung disease. Am. Rev. Respir. Dis. 1985;132:576–581
  6. Staugas R, Martin AJ, Binns G, Steven IM. The significance of fat-filled macrophages in the diagnosis of aspiration associated with gastro-oesophageal reflux. Aust. Paediatr. J. 1985;21:275–277
  7. Nussbaum E, Maggi CJ, Mathis R, Galant SP. Association of lipid-laden alveolar macrophages and gastroesophageal reflux in children. J. Pediatr. 1987;110:190–194
  8. Parameswaran K, AnvariM , Efthimiadis A, Kamada D, Hargreave FE, Allen CJ. Lipid-Laden macrophages in induced sputum are a marker of oropharyngeal reflux and possible gastric aspiration. Eur. Respir. J. 2000;16:1119–1122
  9. Sacco O, Fregonese B, Silvestri M, Sabatini F, Mattioli G, Rossi GA. Bronchoalveolar lavage and esophageal pH monitoring data in children with “difficult to treat” respiratory symptoms. Pediatr. Pulmonol. 2000;30:313–319
  10. Collins KA, Geisinger KR, Wagner PH, Blackburn KS, Washburn LK, Block SM. The cytologic evaluation of lipid-laden alveolar macrophages as an indicators aspiration pneumonia in young children. Arch. Pathol. Lab. Med. 1995;119:229–231
  11. Colombo JL, Hallberg TK. Recurrent aspiration in children: lipid-laden alveolar macrophage quantitation. Pediatr. Pulmonol. 1987;3:86–89
  12. Krishnan U, Mitchell JD, Tobias V, Day AS, Bohane TD. Fat laden macrophages in tracheal aspirates as a marker of reflux aspiration: a negative report. J. Pediatr. Gastroenterol. Nutr. 2002;35:309–313
  13. Rosen R, Fritz J, Nurko A, Simon D, Nurko S. Lipid-laden macrophage index is not an indicator of gastroesophageal reflux-related respiratory disease in children. Pediatrics. 2008;121:879–884
  14. Roth B, Rose KG, Benz-Bohm G, Gunther H. Laryngotracheoesophageal cleft: clinical features, diagnosis and therapy. Eur. J. Pediatr. 1983;140:40–46
  15. Parsons DS, Stivers FE, Giobanetto DR, Phillips SE. Type I posterior laryngeal clefts. Laryngoscope. 1998;108:403–410
  16. Boseley M, Ashland J, Hartnick J. The utility of the fiberoptic endoscopic evaluation of swallowing (FEES) in diagnosing and treating children with type I laryngeal clefts. Int. J. Pediatr. Otorhinolaryngol. 2007;71:1717–1723
  17. Eriksen C, Zwillengerg D, Robinson N. Diagnosis and management of cleft larynx. Literature review and case report. Ann. Otol. Rhinol. Laryngol. 1990;99:703–708
  18. Watters K, Russell J. Diagnosis and management of type 1 laryngeal cleft. In. J. Pediatr. Otorhionlaryngol. 2003;67:591–596
  19. Wolfson PJ, Schloss MD, Guttman FM, Nguyen L. Laryngotracheoesophageal cleft: an easily missed malformation. Arch. Surg. 1984;119:228–230
  20. Myer CM, Cotton RT, Holmes DK, Jackson RK. Laryngeal and laryngotracheoesophageal clefts: role of early surgical repair. Ann. Otol. Rhinol. Layrngol. 1990;99:98–104
  21. Kazachkov MY, Muhlebach MS, Livasy CA, Noah TL. Lipid-laden macrophage index and inflammation in brochoalveolar lavage fluids in children. Eur. Respir. J. 2001;18:790–795
  22. Furuya ME, Moreno-Córdova V, Ramírez-Figueroa JL, Vargas MH, Ramón-García G, Ramírez-San Juan DH. Cutoff value of lipid-laden alveolar macrophages for diagnosing aspiration in infants and children. Pediatr. Pulmonol. 2007;42:452–457
  23. Pezzettigotta SM, Leboulanger N, Roger G, Denoyelle F, Garabédian EN. Laryngeal cleft. Otolaryngol. Clin. North Am. 2008;41:913–923

 This paper was presented at the Triological society eastern section meeting, held in Boston, MA, USA on the 24th January 2009.

PII: S0165-5876(10)00123-0

doi: 10.1016/j.ijporl.2010.03.028

International Journal of Pediatric Otorhinolaryngology
Volume 74, Issue 7 , Pages 743-746 , July 2010