International Journal of Pediatric Otorhinolaryngology
Volume 74, Issue 4 , Pages 361-364 , April 2010

Ototoxicity caused by once- and twice-daily administration of amikacin in rabbits

  • Pavlos Pavlidis

      Affiliations

    • 2nd Department of Otolaryngology, School of Medicine, Aristotle University, Papageorgiou G.H., Thessaloniki, Greece
    • 2nd Laboratory of Pharmacology, School of Medicine, Aristotle University of Thessaloniki, Greece
    • Department of Otolaryngology, School of Medicine, University of Thessaly, Larissa, Greece
    • ,
  • Vasilios Nikolaidis

      Affiliations

    • 2nd Department of Otolaryngology, School of Medicine, Aristotle University, Papageorgiou G.H., Thessaloniki, Greece
    • ,
  • Haralampos Gouveris

      Affiliations

    • Department of Otolaryngology, School of Medicine, University of Thessaly, Larissa, Greece
    • ,
  • Elias Papadopoulos

      Affiliations

    • Veterinary School, Aristotle University of Thessaloniki, Greece
    • ,
  • Georgios Kekes

      Affiliations

    • 2nd Department of Otolaryngology, School of Medicine, Aristotle University, Papageorgiou G.H., Thessaloniki, Greece
    • ,
  • Dimitrios Kouvelas

      Affiliations

    • 2nd Laboratory of Pharmacology, School of Medicine, Aristotle University of Thessaloniki, Greece
    • Corresponding Author InformationCorresponding author at: P.O. Box 1532, 54006 Thessaloniki, Greece. Tel.: +30 2310 999335; fax: +30 2310 999335.

Received 6 July 2009 ,Revised 21 December 2009 ,Accepted 22 December 2009.

References 

  1. Schacht J. Biochemical basis of aminoglycoside ototoxicity. Otolaryngol. Clin North Am. 1993;26:845–856
  2. Isaksson B, Nilsson L, Maller R, Soren L. Post-antibiotic effect of aminoglycosides on gram-negative bacteria evaluated by a new method. J. Antimicrob. Chemother. 1988;22:23–33
  3. Preston SL, Briceland LL. Single daily dosing of aminoglycosides. Pharmacotherapy. 1995;15:297–316
  4. Bates AD, Nahata MC. Once-daily administration of aminoglycosides. Ann. Pharmacother. 1994;28:757–766
  5. Schumock GT, Raber SR, Crawford SY, Naderer OJ, Rodvold KA. National survey of once-daily dosing of aminoglycoside antibiotics. Pharmacotherapy. 1995;15:201–209
  6. Bailey TC, Little JR, Littenberg B, Reichley RM, Dunagan WC. A meta-analysis of extended-interval dosing versus multiple daily dosing of aminoglycosides. Clin. Infect. Dis. 1997;24:786–795
  7. Rybak MJ, Abate BJ, Kang SL, Ruffing MR, Stephen A, Lerner SA, et al. Prospective evaluation of the effect of an aminoglycoside dosing regimen on rates of observed nephrotoxicity and ototoxicity. Antimicrob. Agents Chemother. 1999;43:1549–1555
  8. Manning PJ, Ringler DH, Christian E. The Biology of the Laboratory Rabbit. 2nd ed.. New York, NY: Academic Press; 1994;pp. 468–469
  9. Martin GK, Jassir D, Stagger BB, Lonsbury-Martin BL. Effects of loop diuretics on the suppression tuning of distortion-product otoacoustic emissions in rabbits. J. Acoust. Soc. Am. 1998;104:972–983
  10. Danielidis V, Tsimpiris N, Balatsouras DG, Polychronidis A, Perente S, Papadopoulos N, et al. Short-term pathophysiologic changes and histopathologic findings of the auditory pathway after closed head injury, using a rabbit model. Audiol. Neurootol. 2007;12:145–154
  11. Porter CA, Martin GK, Stanger BB, Lonsbury-Martin BL. Distortion-product otoacoustic emission suppression growth in normal and noise-exposed rabbits. J. Acoust. Soc. Am. 2006;120:884–900
  12. Morawski K, Telischi FF, Merchant F, Abie LW, Lisowska G, Namyslowski G. Role of mannitol in reducing postischemic changes in distortion-product otoacoustic emissions. Laryngoscope. 2003;113:1615–1622
  13. Howard MA, Stagner BB, Losbury-Martin BL, Martin GK. Effects of reversible noise exposure on the suppression tuning of rabbit distortion-product otoacoustic emission. J. Acoust. Soc. Am. 2002;111:285–296
  14. Moore RD, Lietman PS, Craig RS. Clinical response to aminoglycoside therapy: importance of the ratio of peak concentration to minimal inhibitory concentration. J. Infect. Dis. 1987;155:93–99
  15. Morawski K, Telischi FF, Merchant F, Abie LW, Lisowska G, Namyslowski G. Role of mannitol in reducing postischemic changes in distortion-product otoacoustic emissions (DPOAEs): a rabbit model. Laryngoscope. 2003;113:1615–1622
  16. Stagner BB, Martin GK, Lonsbury-Martin BL. Visualization of the onset of distortion-product otoacoustic emissions, and measurement of their latency. J. Acoust. Soc. Am. 1996;100:1663–1679
  17. Hutchin T, Cortopassi G. Proposed molecular and cellular mechanism for aminoglycoside ototoxicity. Antimicrob. Agents Chemother. 1994;38:2517–1520
  18. Hess K. Vestibulotoxic drugs and other causes of acquired bilateral peripheral vestibulopathy. In:  Baloh RW,  Halmagyi GM editor. Disorders of the Vestibular System. New York, NY: Oxford University Press; 1996;p. 360–373
  19. Basile AS, Huang JM, Xie C, Webster D, Berlin C, Skolnick P. N-methyl-d-aspartate antagonists limit aminoglycoside antibiotic hearing loss. Nat. Med. 1996;2:1338–1343
  20. Dulon D, Hiel H, Aurousseau C, Erre JP, Aran JM. Pharmacokinetics of gentamicin in the sensory hair cells of the organ of Corti: rapid uptake and long term persistence. C. R. Acad. Sci. III. 1993;316:682–687
  21. Stavroulaki P, Vossinakis IC, Dinopoulou D, Doudounakis S, Adamopoulos G, Apostolopoulos N. Otoacoustic emissions for monitoring aminoglycoside-induced ototoxicity in children with cystic fibrosis. Arch. Otolaryngol. Head Neck Surg. 2002;128:150–155
  22. Ress BD, Sridhar KS, Balkany TJ, Waxman GM, Stagner Ba BB, Lonsbury-Martin BL. Effects of cis-platinum chemotherapy on otoacoustic emissions: the development of an objective screening protocol. Otolaryngol. Head Neck Surg. 1999;121:693–701Erdem T, Ozturan O, Iraz M, Miman MC, Olmez E. Dose-dependent dual effect of melatonin on ototoxicity induced by amikacin in adult rats. Eur. Arch. Otorhinolaryngol. 2005;262:314–321
  23. Ali MZ, Goetz MB. A meta-analysis of the relative efficacy and toxicity of single daily dosing versus multiple daily dosing of aminoglycosides. Clin. Infect. Dis. 1997;24:796–809
  24. Gouveris H, Victor A, Mann WJ. Cochlear origin of early hearing loss in vestibular schwannoma. Laryngoscope. 2007;117:680–683
  25. Chen Y, Huang WG, Zha DJ, Qiu JH, Wang JL, Sha SH, et al. Aspirin attenuates gentamicin ototoxicity from the laboratory to the clinic. Hear Res. 2007;226:178–182
  26. Galloe AM, Graudal N, Christensen HR, Kampmann JP. Aminoglycosides: single or multiple daily dosing? A meta-analysis on efficacy and safety. Eur. J. Clin. Pharmacol. 1995;48:39–43
  27. Maller R, Ahrne H, Holmen C, Lausen I, Nilsson LE, Smedjegard J. Once-versus twice-daily amikacin regimen: efficacy and safety in systemic Gram-negative infections. J. Antimicrob. Chemother. 1993;31:939–948
  28. Maller R, Ahrne H, Eilard T, Eriksson I, Lausen I. Efficacy and safety of amikacin in systemic infections when given as a single daily dose or in two divided doses. J. Antimicrob. Chemother. 1991;27(Suppl. C):121–128

PII: S0165-5876(10)00002-9

doi: 10.1016/j.ijporl.2009.12.018

International Journal of Pediatric Otorhinolaryngology
Volume 74, Issue 4 , Pages 361-364 , April 2010

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