International Journal of Pediatric Otorhinolaryngology
Volume 73, Issue 12 , Pages 1657-1665 , December 2009

The role of Toll-like receptor 4 in eliciting acquired immune responses against nontypeable Haemophilus influenzae following intranasal immunization with outer membrane protein

Received 4 June 2009 ,Revised 12 August 2009 ,Accepted 14 August 2009.

References 

  1. Berman S. Otitis media in children. N. Engl. J. Med. 1995;332:1560–1565
  2. Brook I, Gober AE. Microbiologic characteristics of persistent otitis media. Arch. Otolaryngol. Head Neck Surg. 1998;124:1350–1352
  3. Commisso R, Romero-Orellano F, Montanaro PB, Romero-Moroni F, Romero-Diat R. Acute otitis media: bacteriology and bacterial resistance in 205 pediatric patients. Int. J. Pediatr. Otorhinolaryngol. 2000;56:23–31
  4. Kodama S, Suenaga S, Hirano T, Suzuki M, Mogi G. Induction of specific immunoglobulin A and Th2 immune responses to P6 outer membrane protein of nontypeable Haemophilus influenzae in middle ear mucosa by intranasal immunization. Infect. Immun. 2000;68:2294–3000
  5. Sabirov A, Kodama S, Hirano T, Suzuki M, Mogi G. Intranasal immunization enhances clearance of nontypeable Haemophilus influenzae and reduces stimulation of tumor necrosis factor alpha production in the murine model of otitis media. Infect. Immun. 2001;69:2964–2971
  6. Kurono Y, Suzuki M, Mogi G, Yamamoto M, Fujihashi K, McGhee JR, et al. Effects of intranasal immunization on protective immunity against otitis media. Int. J. Pediatr. Otorhinolaryngol. 1999;S227–S229
  7. Kurono Y, Yamamoto M, Fujihashi K, Kodama S, Suzuki M, Mogi G, et al. Nasal immunization induces Haemophilus influenzae-specific Th1 and Th2 responses with mucosal IgA and systemic IgG antibodies for protective immunity. J. Infect. Dis. 1999;180:122–132
  8. Takeda K, Kaisho T, Akira S. Toll-like receptors. Annu. Rev. Immunol. 2003;21:335–376
  9. Yarovinsky F, Zhang D, Andersen JF, Bannenberg GL, Serhan CN, Hayden MS, et al. TLR11 activation of dendritic cells by a protozoan profilin-like protein. Science. 2005;308:1626–1629
  10. Agnese DM, Calvano JE, Hahm SJ, Coyle SM, Corbett SA, Calvano SE, et al. Human Toll-like receptor 4 mutations but not CD14 polymorphisms are associated with an increased risk of Gram-negative bacteria infections. J. Infect. Dis. 2002;186:1522–1525
  11. Faber J, Meyer CU, Gemmer C, Russo A, Finn A, Murdoch C, et al. Human Toll-like receptor 4 mutations are associated with susceptibility to invasive meningococcal disease in infancy. Pediatr. Infect. Dis. J. 2006;25:80–81
  12. Eisenbarth SC, Piggott DA, Huleatt JW, Visintin I, Herrick CA, Bottomly K. Lipopolysaccharide-enhanced, Toll-like receptor 4-dependent T helper cell type 2 responses to inhaled antigen. J. Exp. Med. 2002;196:645–1651
  13. Dabbagh K, Dahl ME, Stepick BP, Lewis DB. Toll-like receptor 4 is required for optimal development of Th2 immune responses: role of dendritic cells. J. Immunol. 2002;168:4524–4530
  14. Openshaw P, Murphy EE, Hosken NA, Manio V, Davis K, Murphy K, et al. Heterogeneity of intracellular cytokine synthesis at the single-cell level in polarized T helper 1 and T helper 2 populations. J. Exp. Med. 1995;182:1357–1367
  15. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2ΔΔCT method. Method. 2001;25:402–408
  16. Wu TH, Gu XX. Outer membrane proteins as a carrier for detoxified lipooligosaccharide conjugate vaccines for nontypeable Haemophilus influenzae. Infect. Immun. 1999;67:5508–5513
  17. Xu-Amano J, Jackson RJ, Fujihashi K, Kiyono H, Staats HF, McGhee JR. Helper Th1 and Th2 cell responses following mucosal or systemic immunization with cholera toxin. Vaccine. 1994;12:903–911
  18. Sonoda E, Hitoshi Y, Yamaguchi N, IshiI T, Tominaga A, Araki S, et al. Differential regulation of IgA production by TGF-beta and IL-5:TGF-beta induces surface IgA-positive cells bearing IL-5 receptor, whereas IL-5 promotes their survival and maturation into IgA-secreting cells. Cell Immunol. 1992;140:158–172
  19. Beagley KW, Eldridge JH, Kiyono H, Everson MP, Koopman WJ, Honjo T, et al. Recombinant murine IL-5 induces high rate IgA synthesis in cycling IgA-positive Peyer's patch B cells. J. Immunol. 1988;141:2035–2042
  20. Stevens TL, Bossie A, Sanders VM, Fernandez-Botran R, Coffman RL, Mosmann TR, et al. Regulation of antibody isotype secretion by subsets of antigen-specific helper T cells. Nature. 1988;334:255–258
  21. Kjerrulf M, Grdic D, Ekman L, Schön K, Vajdy M, Lycke NY. Interferon-gamma receptor-deficient mice exhibit impaired gut mucosal immune responses but intact oral tolerance. Immunology. 1997;92:60–68
  22. Hashizume T, Togawa A, Nochi T, Igarashi O, Kweon MN, Kiyono H, et al. Peyer's patches are required for intestinal immunoglobulin A responses to Salmonella spp.. Infect. Immun. 2008;76:927–934
  23. Godding V, Sibille Y, Massion PP, Delos M, Sibille C, Thurion P, et al. Secretory component production by human bronchial epithelial cells is upregulated by interferon gamma. Eur. Respir. J. 1998;11:1043–1052
  24. Mazzoni A, Segal DM. Controlling the Toll road to dendritic cell polarization. J. Leukoc. Biol. 2004;75:721–730
  25. Kunimoto DY, Harriman GR, Strober W. Regulation of IgA differentiation in CH12LX B cells by lymphokines. IL-4 induces membrane IgM-positive CH12LX cells to express membrane IgA and IL-5 induces membrane IgA-positive CH12LX cells to secrete IgA. J. Immunol. 1988;141:713–720
  26. Shockett P, Stavnezer J. Effect of cytokines on switching to IgA and a germline transcripts in the B lymphoma I.29mu. Transforming growth factor-beta activates transcription of the unrearranged Ca gene. J. Immunol. 1991;147:4374–4383
  27. Hodgkin PD, Yamashita LC, Seymour B, Coffman RL, Kehry MR. Membranes from both Th1 and Th2 T cell clones stimulate B cell proliferation and prepare B cells for lymphokine-induced differentiation to secrete Ig. J. Immunol. 1991;147:3696–3702
  28. Defrance T, Vanbervliet B, Briere F, Durand I, Rousset F, Banchereau J. Interleukin 10 and transforming growth factor beta cooperate to induce anti-CD40-activated naive human B cells to secrete immunoglobulin A. J. Exp. Med. 1992;175:671–682
  29. Shuto T, Xu H, Wang B, Han J, Gu XX, et al. Activation of NF-kappa B by nontypeable Hemophilus influenzae is mediated by Toll-like receptor 2-TAK1-dependent NIK-IKK alpha/beta-I kappa B alpha and MKK3/6-p38 MAP kinase signaling pathways in epithelial cells. Proc. Natl. Acad. Sci. U.S.A. 2001;98:8774–8779

PII: S0165-5876(09)00433-9

doi: 10.1016/j.ijporl.2009.08.015

International Journal of Pediatric Otorhinolaryngology
Volume 73, Issue 12 , Pages 1657-1665 , December 2009