International Journal of Pediatric Otorhinolaryngology
Volume 73, Issue 12 , Pages 1653-1656, December 2009

Changes in IGF-I, IGFBP-3 and ghrelin levels after adenotonsillectomy in children with sleep disordered breathing

  • Murat Gümüssoy

      Affiliations

    • Ondokuz Mayis University School of Medicine, Dept. of Otolaryngology, Samsun, Turkey
    • ,
  • Sinan Atmaca

      Affiliations

    • Ondokuz Mayis University School of Medicine, Dept. of Otolaryngology, Samsun, Turkey
    • Corresponding Author InformationCorresponding author. Tel.: +90 505 9212687; fax: +90 362 4576041.
    • ,
  • Birsen Bilgici

      Affiliations

    • Ondokuz Mayis University School of Medicine, Dept. of Biochemistry, Samsun, Turkey
    • ,
  • Recep Ünal

      Affiliations

    • Ondokuz Mayis University School of Medicine, Dept. of Otolaryngology, Samsun, Turkey

Received 24 March 2009; received in revised form 12 August 2009; accepted 14 August 2009.

Abstract 

Objective

The aim of this study was to determine the changes in insulin-like growth factor-I (IGF-I), insulin-like growth factor binding protein-3 (IGFBP-3) and ghrelin levels following adenotonsillectomy (T&A) in children with sleep disordered breathing (SDB).

Methods

Forty children (mean age 4.85±2.15 years) clinically diagnosed with adenotonsillar hypertrophy (ATH) related SDB were enrolled. All children underwent T&A. Serum levels of IGF-I, IGFBP-3 and ghrelin were measured before and 6 months after T&A.

Results

Serum levels of IGF-I and IGFBP-3 were significantly higher after T&A (p<0.001). Serum ghrelin levels showed a significant decrease after T&A (p<0.001).

Conclusion

Children with ATH related SDB who underwent T&A showed significant increases in IGF-I and IGFBP-3 levels indicating an increase in diurnal growth hormone secretion as well as a significant decrese in ghrelin levels indicating an increased oral food intake in the postoperative period.

Keywords: IGF-I, IGFBP-3, Ghrelin, Adenotonsillar hypertrophy, Sleep disordered breathing, Adenotonsillectomy

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PII: S0165-5876(09)00432-7

doi:10.1016/j.ijporl.2009.08.025

International Journal of Pediatric Otorhinolaryngology
Volume 73, Issue 12 , Pages 1653-1656, December 2009

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