International Journal of Pediatric Otorhinolaryngology
Volume 63, Issue 2 , Pages 111-118 , 25 April 2002

A preventive measure for otitis media in children with upper respiratory tract infections

Received 19 May 2001 ,Revised 4 December 2001 ,Accepted 8 December 2001.

References 

  1. André MJ. Infections of the ear, nose and throat. In: Essential of Infectious Diseases. Oxford: Blackwell Scientific Publications; 1985;p. 155–173
  2. Liu C. Sinusitis. In:  f-Hoeprich PD,  Jordan MC editor. Infectious Diseases. 4th ed.. Philadelphia: JP Lippincott Company; 1989;p. 293–295
  3. Current Estimates from the National Health Interview Survey, 1993. Vital Health Stat. 1994;190:1–221
  4. Bellanti JA. Recurrent respiratory tract infections in paediatric patients. Drugs. 1997;54(Suppl. 1):1–4
  5. Stewart MG, Manolidis S, Wynn R, Bautista M. Practice patterns versus practice guidelines in paediatric otitis media. Otolaryngol. Head Neck Surg. 2001;124:489–495
  6. Banz K, Thomas AM, Olivieri D. Economic evaluation of ribosomal immunotherapy in patients with chronic ear, nose and throat and respiratory tract infections: results for Italy. BioDrugs. 1998;10:385–396
  7. Chen CF, Wu KG, Hsu MC, Tang RB. Prevalence and relationship between allergic diseases and infectious diseases. J. Microbiol. Immunol. Infect. 2001;34(1):57–62 March
  8. Berdeaux G, Lafuma A, Perruchet A-M, et al.  Cost effectiveness of immunoprophylaxis in the prevention of recurrent infectious rhinitis in adults. Phartnacoeconomics. 1998;14:313–322
  9. Vesa S, Kleemola M, Blomqvist S, Takala A, Kilpi T, Hovi T. Epidemiology of documented viral respiratory infections and acute otitis media in a cohort of children followed from two to twenty-four months of age. Pediatr. Infect. Dis. J. 2001;20(6):574–581 June
  10. Fiocchi A, Arancio R, Cinquepalmi P, et al.  Recurrent respiratory infections in childhood: experience with a bacterial extract plus bacterial ribosomes (Immucytol®). J. Int. Med. Res. 1990;18:50–60
  11. Puigdollers JM, Rodesserna G, Hernandez Del Rey I, et al.  Immunoglobulin production in man stimulated by orally administered bacterial lysate (Broncho-Vaxom). Respiration. 1980;40:142–145
  12. Bousquet J, Dussourd d'Hinterland L. Prevention of bacterial respiratory infections using a ribosomal vaccine [in French]. Méd. Hyg. 1982;40:146–157
  13. Czerkinsky C, Russel MW, Lycke N, et al.  Oral administration of streptococcal antigen coupled to cholera toxin B subunit evokes strong antibody responses in salivary glands and extramucosal tissues. Infect. Immun. 1989;57:1072
  14. Bessler WG, Sadelmeir E. Biological activity of bacterial cell wall components: immunogenicity of an immunostimulating bacterial extract. Arzneim.-Forsch. (Drug Res.). 1993;43:502–507
  15. McGhee JR, Mestecky J, Dertzbaugh MT, et al.  The mucosal immune system. From fundamental concepts-to vaccine development. Vaccine. 1992;10:75–88
  16. Galloro 68 et al. Bacterial adherence and upper respiratory tract disease; a correlation between S. pyogenes attachment and recurrent throat infections, Acta Otorhinolaryngol. 454 (Suppl.) (1988) 167–174.
  17. Mega J, McGhee JR, Kiyono H. Cytokine and Ig-producing cells in mucosal effector tissues analysis of IL-5 and IFN-y producing cells, T cells, T cell receptor expression and IGA plasma cells from mouse salivary gland-associated tissues. J. Immunol. 1992;148:2030–2039
  18. J. Mestecky, J.R. McGhee, Immunoglobulin A (IgA): molecular and cellular interactions in volved in IgA biosynthesis and immune response, Adv. Immunol. 40 (1987) 153.
  19. Brandtzaeg P. Overview of the mucosal immune system. Curr. Top. Microbiol. 1990;140:13
  20. J. Mestecky, The common mucosal immune system and current strategies far induction of immune responses in external secretions, J. Clin. Immunol. 7 (1987) 265.
  21. Ramstadt U. Stimulation of NK cells using Klebsiella Pneumoniae membrane proteoglycans. Maladies Médicaments. 1987;3:25–36
  22. Allavena P, Annalaura E, Pirelli A, et al.  Stimulation of cytotoxic and non-cytotoxic functions of natural killer cells by bacterial membrane proteoglycans and ribosomes. Int. J. Immunopharmacol. 1989;11:29–34
  23. Luini W, De Rossi M, Licciardello L, et al.  Chemotactic cytokine gene expression and production induced in human monocytes by membrane proteoglycans from Klebsiella Pneumoniae. Int. J. Immunopharmacol. 1991;13:631–637
  24. Pujol JL, Klein B, Godard P, et al.  Bacterial ribosomal immunostimulants prime alveolar macrophages in vivo to produce interleukin 1 in vitro. Chest. 1991;100:644–648
  25. Roques C, Frayret MN, Luc J, et al.  Effect of an in vivo immunostimulant treatment on PMN functions: interaction with antibiotics in vitro. Int. J. Immunopharmacol. 1991;13:1051–1057
  26. Roques C, Frayret MN, Luc J, et al.  Immunostimulant effects on granulocyte functions during an acute respiratory infection. Dev. Biol. Stand. 1992;77:183–187
  27. Zanin C, Perrin P, Béné MC, et al.  Antibody-producing cells in peripheral blood and tonsils after oral treatment of children with bacterial ribosomes. Int. J. Immunopharmacol. 1994;16:497–505
  28. A. Vierucci, M. De Martino, et al. Recurrent respiratory infections in children [in Italian], Proceedings of the meeting ‘Aggiornamenti in Pediatria’, J. Miniato, Pisa, 11 December 1982.
  29. Giovannini M, Fiocchi A, Sala M, et al.  Immucytal in the prevention and treatment of recurrent upper respiratory tract infections in children: a randomised, placebocontrolled, double-blind study. Int. J. Immunother. 2000;3–4:6
  30. Lacomme Y, Narcy P. Efficacy of Ribomunyl in the prevention of recurrent upper respiratory tractinfections [in French]. Immunol. Méd. 1985;11:73–75
  31. Biolchini A, Cierici Scholler M, Carddu P. Clinical experience with Biomunil tablets in children with recurrent respiratory infections. Eur. Respir. J. 1991;4(Suppl. 14):207S
  32. Baraldi E, Santuz PA, Zacchello F. Prophylaxis of recurrent respiratory infections in children with a new immunomodulating agent. Eur. Respir. J. 1991;4(Suppl. 14):208S
  33. E.N. Garabedian, C. Dubreuil, J.C. Triglia, Effectiveness and tolerance of Ribomunyl tablets in preventing middle ear infections in children affected by SOM, International Congress on Prevention of Infection, Nice, France, 1990.
  34. Haguenauer JP. Prevention of recurrent ear, nose and throat infections with Ribomunyl tablets in children aged less than 5 years [in French]. Immunol. Méd. 1987;18:36–39
  35. Vautel JM, Cauquil J, Perruchet AM, et al.  Prevention of recurrent ear, nose and throat infections in young children with Ribomunyl: double-blind, placebo-controlled study. Curr. Ther. Res. 1993;53:722–729
  36. Serrano E, Demanez JP, Morgon A, et al.  Effectiveness of ribosomal fractions of Klebsiella pneumoniae, Streptococcus pneumoniae, Streptococcus pyogenes, Haemophilus influenzae and the membrane fracfion of Kp (Riboomunyl) in the prevention of clinical recurrences of infectious rhinitis: results of a multicenter double-blind placebo-controlled study. Eur. Arch. Otorhinolaryngol. 1997;254(8):372–375
  37. M. Sapene, J.P. Grignet, A.M. Perruchet, Epidemiologic and therapeutic survey: chronic bronchitis and asthma, Congress of the European Respiratory Society, London, 1990.
  38. Y. Benchakroun, Z. Bouayad, I. Chekkouri et al., Prevention of respiratory infections recurrences by Ribomunyl® tablets. Results of a multicentre clinical study in Marocco [in French], Object Méd. Mog. (1994) October.
  39. Debas J. Relapsing tonsillitis: prevention with a ribosomal vaccine. In:  Sacristàn T,  Alvarez-Vicent JJ,  Antolı̀-Candela F, et al. editor. Otorhinolaryngology, Head & Neck Surgery. Amsterdam: Kugler & Ghedini Publications; 1990;p. 2883–2885
  40. P. Léophonte, J.C. Guerin, G. Nouvet et al., Congrés de Pneumonologie de Langue Francaise, Algiers, 1989.
  41. Girard JP, Gumovski PI, Chavaz A, et al.  Place of different forms of Ribomunyl in the treatment of recurrent respiratory tract infections [in French]. Schwiez Med Wochenschr. 1988;118:856–861
  42. Hadi U, Matar GM. Bacterial etiology of otitis media with effusion in a group of Lebanese children. J. Med. Liban. 2000;48(3):143–146 May–June

PII: S0165-5876(01)00649-8

International Journal of Pediatric Otorhinolaryngology
Volume 63, Issue 2 , Pages 111-118 , 25 April 2002