International Journal of Pediatric Otorhinolaryngology
Volume 63, Issue 2 , Pages 99-110 , 25 April 2002

Histopathologic differences due to bacterial species in acute otitis media

Received 24 August 2001 ,Revised 30 November 2001 ,Accepted 3 December 2001.

References 

  1. Alho OP, Koivu M, Sorri M, et al.  The occurrence of acute otitis media in infants. A life-table analysis. Int. J. Pediatr. Otorhinolaryngol. 1991;21:7–14
  2. Pukander J, Luotonen J, Sipila M, et al.  Incidence of acute otitis media. Acta Otolaryngol. (Stockholm). 1982;93:447–453
  3. Stangerup SE, Tos M. Epidemiology of acute suppurative otitis media. Am. J. Otolaryngol. 1986;7:47–54
  4. Teele DW, Klein JO, Rosner B. Epidemiology of otitis media during the first seven years of life in children in greater Boston: a prospective, cohort study. J. Infect. Dis. 1989;160:83–94
  5. Karma P, Perala M, Kuusela AL. Morbidity of very young infants with and without acute otitis media. Acta Otolaryngol. (Stockholm). 1989;107:460–466
  6. Stool SE, Field MJ. The impact of otitis media. Pediatr. Infect. Dis. J. 1989;8:S11–S14
  7. S.M. Schappert, Office visits for otitis media: United States, 1975–90, Adv. Data Sep. 8 (1992) 1–19.
  8. Zimmerman DR, Allegra JR, Cody RP. The epidemiology of pediatric visits to New Jersey general emergency departments. Pediatr. Emerg. Care. 1998;14:112–115
  9. Alsarraf R, Jung CJ, Perkins J, et al.  Measuring the indirect and direct costs of acute otitis media. Arch. Otolaryngol. Head Neck Surg. 1999;125:12–18
  10. Karma PH, Penttila MA, Sipila MM, et al.  Otoscopic diagnosis of middle ear effusion in acute and non-acute otitis media. I. The value of different otoscopic findings. Int. J. Pediatr. Otorhinolaryngol. 1989;17:37–49
  11. Karma P, Sipila M, Kataja M, Penttila MA. Pneumatic otoscopy and otitis media. II. Value of different tympanic membrane findings and their combinations. In:  Lim DJ,  Bluestone C,  Klein JO, et al. editor. Recent Advances in Otitis Media. Ontario, Canada: BC Decker; 1993;p. 41–45
  12. Klein JO, Tos M, Hussl B, et al.  Recent advances in otitis media. Definition and classification. Ann. Otol. Rhinol. Laryngol. Suppl. 1989;139:10
  13. Lundgren K, Ingvarsson L. Microbiology in acute otitis media. In:  Sade J editors. Acute and Secretory Otitis Media. Amsterdam, The Netherlands: Kugler Publications; 1986;p. 175–179
  14. Luotonen J, Herva E, Karma P, et al.  The bacteriology of acute otitis media in children with special reference to Streptococcus pneumoniae as studied by bacteriological and antigen detection methods. Scand. J. Infect. Dis. 1981;13:177–183
  15. Stephenson JS, Martin LM, Kardatzke D, Bluestone C. Prevalence of bacteria in middle ear effusions for the 1980s. In:  Lim DJ,  Bluestone C,  Klein JO, et al. editor. Recent Advances in Otitis Media. Ontario, Canada: BC Decker; 1993;p. 389–392
  16. Goldstein NA, Casselbrant ML, Bluestone CD, et al.  Intratemporal complications of acute otitis media in infants and children. Otolaryngol. Head Neck Surg. 1998;119:444–454
  17. Kangsanarak J, Fooanant S, Ruckphaopunt K, et al.  Extracranial and intracranial complications of suppurative otitis media. Report of 102 cases. J. Laryngol. Otol. 1993;107:999–1004
  18. Hayman L. Experimentelle studien zur pathologie der akut-entzündlichen prozesse im mittelohr. Arch. Ohrenheilk. 1913;90:267–309
  19. L. Hayman, Experimentelle studien zur pathologie der akut-entzündlichen prozesse im mittelohr, Arch Ohrenheilk 92 (1913) 1–73 and 161–214.
  20. Hayman L. Experimentelle studien zur pathologie der akut-entzündlichen prozesse im mittelohr. Arch. Ohrenheilk. 1913;93:1–58
  21. Hayman L. Experimentelle studien zur pathologie der akut-entzündlichen prozesse im mittelohr. Arch. Ohrenheilk. 1913;95:99–144
  22. I. Friedmann, The comparative pathology of otitis media-experimental and human, J. Laryngol. Otol. 69 (1955) 27–50 and 588–601.
  23. Lim DJ, Klainer A. Cellular reactions in acute otitis media-scanning and transmission electron microscopy. Laryngoscope. 1971;81:1772–1786
  24. Meyerhoff WL, Shea DA, Giebink GS. Experimental pneumococcal otitis media: a histopathologic study. Otolaryngol. Head Neck Surg. 1980;88:606–612
  25. Lowell SH, Juhn SK, Giebink GS. Experimental otitis media following middle ear inoculation of nonviable Streptococcus pneumoniae. Ann. Otol. Rhinol. Laryngol. 1980;89:479–482
  26. Meyerhoff WL, Giebink GS, Shea D. Pneumococcal otitis media following middle ear deflation. Ann. Otol. Rhinol. Laryngol. 1981;90:72–76
  27. Okazaki N, Demaria TF, Briggs BR, et al.  Experimental otitis media with effusion induced by nonviable Hemophilus influenzae: cytologic and histologic study. Am. J. Otolaryngol. 1984;5:80–92
  28. Grote JJ, van Blitterswijk CA. Acute otitis media. An animal experimental study. Acta Otolaryngol. (Stockholm). 1984;98:239–249
  29. Giebink GS, Ripley ML, Shea DA, et al.  Clinical–histopathological correlations in experimental otitis media: implications for silent otitis media in humans. Pediatr. Res. 1985;19:389–396
  30. Fulghum RS, Hoogmoed RP, Brinn JE, et al.  Experimental pneumococcal otitis media: longitudinal studies in the gerbil model. Int. J. Pediatr. Otorhinolaryngol. 1985;10:9–20
  31. Fulghum RS, Hoogmoed RP, Brinn JE. Longitudinal studies of experimental otitis media with Haemophilus influenzae in the gerbil. Int. J. Pediatr. Otorhinolaryngol. 1985;9:101–114
  32. Demaria TF, Yamaguchi T, Lim DJ. Quantitative cytologic and histologic changes in the middle ear after the injection of nontypable Hemophilus influenzae endotoxin. Am. J. Otolaryngol. 1989;10:261–266
  33. Fitzgerald JE, Green GG, Stafford FW, et al.  Characterization of human middle ear mucus glycoprotein in chronic secretory otitis media (CSOM). Clin. Chim. Acta. 1987;169:281–297
  34. Majima Y, Jin CS, Takeuchi K, et al.  Rheological properties of middle ear mucus in relation to goblet cell population in cat. Acta Otolaryngol. Suppl. (Stockholm). 1991;483:11–16
  35. Tos M. Production of mucus in the middle ear and Eustachian tube. Embryology, anatomy, and pathology of the mucous glands and goblet cells in the Eustachian tube and middle ear. Ann. Otol. Rhinol. Laryngol. Suppl. 1974;83:58
  36. Tos M, Bak-Pedersen K. Goblet cell population in the pathological middle ear and eustachian tube of children and adults. Ann. Otol. Rhinol. Laryngol. 1977;86:209–218
  37. Tos M, Bak-Pedersen K. Secretory otitis. Histopathology and goblet-cell density in the Eustachian tube and middle ear in children. J. Laryngol. Otol. 1976;90:475–485
  38. Tos M. Manual of Middle Ear Surgery. Mastoid Surgery and Reconstructive Procedures. 2. New York, USA: Thieme Medical Publishers; 1995;
  39. Tos M. Surgical Solutions for Conductive Hearing Loss. Stuttgart/New York: Thieme; 2000;
  40. da Costa SS, Paparella M, Schachern P, et al.  Temporal bone histopathology in chronically infected ears with intact and perforated tympanic membranes. Laryngoscope. 1992;102:1229–1236
  41. Caye-Thomasen P, Hermansson A, Tos M, et al.  Polyp pathogenesis—a histopathological study in experimental acute otitis media. Acta Otolaryngol. (Stockholm). 1995;115:76–82
  42. Caye-Thomasen P, Hermansson A, Tos M, et al.  Pathogenesis of middle ear adhesions. Laryngoscope. 1996;106:463–469
  43. Caye-Thomasen P, Tos M. Polyp and fibrous adhesion formation in acute otitis media caused by non-typeable or type b Haemophilus influenzae or Moraxella catarrhalis. Acta Otolaryngol. (Stockholm). 2000;120:810–815
  44. Caye-Thomasen P, Hermansson A, Tos M, et al.  Middle ear secretory capacity after acute otitis media caused by Streptococcus pneumoniae, Moraxella catarrhalis, non-typeable or type b Haemophilus influenzae. A comparative analysis based on goblet cell density. Acta Otolaryngol. Suppl. (Stockholm). 2000;543:54–55
  45. Caye-Thomasen P, Hermansson A, Tos M, et al.  Bone modeling dynamics in acute otitis media. Laryngoscope. 1999;109:723–729
  46. Caye-Thomasen P, Tos M. Adaptive bone modeling and remodeling in acute otitis media caused by non-typeable or type b Haemophilus influenzae or Moraxella catarrhalis. Acta Otolaryngol. (Stockholm). 2000;120:815–820
  47. Falla TJ, Dobson SRM, Crook DWM. Population-based study of non-typeable Haemophilus influenzae invasive disease in children and neonates. Lancet. 1993;341:851–854
  48. Friedman EM, McGill TJ, Healy GB. Central nervous system complications associated with acute otitis media in children. Laryngoscope. 1990;100:149–151
  49. Magnuson K, Hermansson A, Melhus A, et al.  The tympanic membrane and middle ear mucosa during non-typeable Haemophilus influenzae and Haemophilus influenzae type b acute otitis media: a study in the rat. Acta Otolaryngol. (Stockholm). 1997;117:396–405
  50. Marchant CD. Spectrum of disease due to Branhamella catarrhalis in children with particular reference to acute otitis media. Am. J. Med. 1990;88:15S–19S
  51. Melhus A, Hermansson A, Prellner K. Nontypeable and encapsulated Haemophilus influenzae yield different clinical courses of experimental otitis media. Acta Otolaryngol. (Stockholm). 1994;114:289–294
  52. Rodriguez WJ, Schwartz RH. Streptococcus pneumoniae causes otitis media with higher fever and more redness of tympanic membranes than Haemophilus influenzae or Moraxella catarrhalis. Pediatr. Infect. Dis. J. 1999;18:942–944
  53. Fulghum RS, Brinn JE, Smith AM, et al.  Experimental otitis media in gerbils and chinchillas with Streptococcus pneumoniae, Haemophilus influenzae, and other aerobic and anaerobic bacteria. Infect. Immun. 1982;36:802–810
  54. Hermansson A, Melhus A, Westman E, et al.  Purulent otitis media caused by different bacteria: a comparison in the rat model. In:  Lim DJ,  Bluestone C,  Casselbrandt ML, et al. editor. Recent Advances in Otitis Media. Ontario, Canada: BC Decker; 1996;p. 516–517
  55. Westman E, Hermansson A, Magnuson K, et al.  Changes in goblet cells in rat middle ear mucosa of purulent otitis media caused by Moraxella catarrhalis, Streptococcus pneumoniae, non-typeable Haemophilus influenzae, and encapsulated Haemophilus influenzae. In:  Lim D,  Bluestone C,  Casselbrandt ML, et al. editor. Recent Advances in Otitis Media. Ontario, Canada: BC Decker; 1996;p. 531–533
  56. Harabuchi Y, Faden H, Yamanaka N, et al.  Nasopharyngeal colonization with nontypeable Haemophilus influenzae and recurrent otitis media. Tonawanda/Williamsville Pediatrics. J. Infect. Dis. 1994;170:862–866
  57. Kamme C, Nilsson NI. Secretory otitis media: microbiology of the middle ear and the nasopharynx. Scand. J. Infect. Dis. 1984;16:291–296
  58. Freijd A, Bygdeman S, Rynnel-Dagöö B. The nasopharyngeal microflora of otitis-prone children, with emphasis on H. influenzae. Acta Otolaryngol. (Stockholm). 1994;97:117–126
  59. Albiin N, Hellström S, Stenfors LE, et al.  Middle ear mucosa in rats and humans. Ann. Otol. Rhinol. Laryngol. Suppl. 1986;126:2–15
  60. Daniel HJ, Fulghum RS, Brinn JE, et al.  Comparative anatomy of eustachian tube and middle ear cavity in animal models for otitis media. Ann. Otol. Rhinol. Laryngol. 1982;91:82–89
  61. Hellström S, Salen B, Stenfors LE. Anatomy of the rat middle ear. A study under the dissection microscope. Acta Anat. (Basel). 1982;112:346–352
  62. Hellström S, Stenfors LE. The pressure equilibrating function of pars flaccida in middle ear mechanics. Acta Physiol. Scand. 1983;118:337–341
  63. Lewis DM, Schram JL, Meadema SJ, et al.  Experimental otitis media in chinchillas. Ann. Otol. Rhinol. Laryngol. Suppl. 1980;89:344–350
  64. Marshak G, Cantekin EI, Doyle WJ, et al.  Recurrent pneumococcal otitis media in the chinchilla. A longitudinal study. Arch. Otolaryngol. 1981;107:532–539
  65. Giebink GS. Animal models of otitis media with effusion. In:  Bernstein J,  Ogra P editor. Immunology of the Ear. New York: Raven Press; 1987;p. 403–418
  66. Daniel HJ, Forrest HC, Cook RA. Otitis media in two strains of laboratory rats. J. Aud. Res. 1971;11:276–278
  67. Offenbartl K, Christensen P, Gullstrand P, et al.  Treatment of pneumococcal postsplenectomy sepsis in the rat with human gammaglobulin. J. Surg. Res. 1986;40:198–201
  68. Hermansson A. Pneumococcal Otitis Media. Treatment and Prevention, Studied in an Animal Model. Sweden: Department of Oto-rhino-laryngology, University Hospital of Lund; 1990;
  69. Westman E, Melhus A, Hellstrom S, et al.  Moraxella catarrhalis-induced purulent otitis media in the rat middle ear. Structure, protection, and serum antibodies. APMIS. 1999;107:737–746
  70. Brooks GF, Butel JS, Morse SA. Jawetz, Melnick & Adelberg's Medical microbiology. Stamford, CT, USA: Appleton & Lange; 1998;
  71. Carlsen BD, Kawana M, Kawana C, et al.  Role of the bacterial cell wall in middle ear inflammation caused by Streptococcus pneumoniae. Infect. Immun. 1992;60:2850–2854
  72. Gu XX, Tsai CM, Apicella MA, Lim DJ. Biologic properties of released and cell-bound endotoxin from nontypeable Haemophilus influenzae. In:  Lim DJ,  Bluestone C,  Casselbrandt ML, et al. editor. Recent Advances in Otitis Media. Ontario, Canada: BC Decker; 1996;p. 476–479
  73. Ripley-Petzoldt ML, Giebink GS, Juhn SK, et al.  The contribution of pneumococcal cell wall to the pathogenesis of experimental otitis media. J. Infect. Dis. 1988;157:245–255
  74. Sato K, Quartey MK, Liebeler CL, et al.  Roles of autolysin and pneumolysin in middle ear inflammation caused by a type 3 Streptococcus pneumoniae strain in the chinchilla otitis media model. Infect. Immun. 1996;64:1140–1145
  75. Svanborg C, Andersson B, Andersson von Rosen I, et al.  Bacterial adherence and acute otitis media. In:  Lim DJ,  Bluestone C,  Klein JO, et al. editor. Recent Advances in Otitis Media. Ontario, Canada: BC Decker; 1993;p. 367–373

PII: S0165-5876(01)00641-3

International Journal of Pediatric Otorhinolaryngology
Volume 63, Issue 2 , Pages 99-110 , 25 April 2002