International Journal of Pediatric Otorhinolaryngology
Volume 59, Issue 2 , Pages 137-141, 14 June 2001

Temporal bone histopathology in trisomy 22

Department of Otolaryngology, Fukushima Medical University, Fukushima 960-1247, Japan

Received 23 December 2000; accepted 24 February 2001.

Abstract 

Trisomy 22 has multiple physical anomalies, and aural malformations are commonly associated with trisomy 22. However, there has been only one report describing the temporal bone histopathology in trisomy 22. Our case is the second reported temporal bone histopathology of trisomy 22. Aural anomalies in this case were less serious than those earlier described, though showing Mondini dysplasia of the bony and membranous labyrinth. Deafness in patients with trisomy 22 may manifest sensorineural, conductive or mixed hearing losses, and/or vestibular dysfunction of varying degrees, according to the site and severity of aural anomalies.

Keywords:  Trisomy 22, Aural anomaly, Histopathology

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PII: S0165-5876(01)00459-1

International Journal of Pediatric Otorhinolaryngology
Volume 59, Issue 2 , Pages 137-141, 14 June 2001

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